| P^53,Bcl—2在皮肤鳞状细胞癌、基底细胞癌脂溢性角化病中联合表达的意义 |
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| 引用本文： | 毛东军 孙咏梅 等. P^53,Bcl—2在皮肤鳞状细胞癌、基底细胞癌脂溢性角化病中联合表达的意义[J]. 齐齐哈尔医学院学报, 2001, 22(2): 121-122 |
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| 作者姓名： | 毛东军 孙咏梅 等 |
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| 作者单位： | 毛东军（江苏省连云港市肿瘤医院,222023） 孙咏梅（江苏省连云港市肿瘤医院,222023） 贾惠英（江苏省连云港市肿瘤医院,222023） 谢秋红（江苏省连云港市肿瘤医院,222023） 沈景刚（江苏省连云港市肿瘤医院,222023） |
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| 摘 要： | 目的：探讨P^53蛋白，Bcl-2蛋白在皮肤鳞状细胞癌（SCC），基底细胞癌（BCC）及脂溢性角化病（SK）中的表达及意义。方法：采用S－P法分别对12例SCC，BCC，SK进行免疫组化P^53蛋白，Bcl－2蛋白检测。结果：12例SCC，BCC中分别有9例，11例P^53蛋白表达阳性有10例，11例Bcl-2蛋白表达阳性，12例SK中有1例P^53表达阳性，11例Bcl-2表达阳性，P^53蛋白在SCC，BCC中表达显著高于SK（P＜0．01）。结论：P53蛋白基因突变和Bcl-2蛋白的过度表达（即细胞凋亡机制）在皮肤恶性肿瘤的发生，发展中起重要促进作用。
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| 关 键 词： | 皮肤肿瘤 鳞状细胞癌 基底细胞癌 脂溢性角化病 免疫组织化学 P^53蛋白 Bcl－2蛋白 |
Expression and Significance of p53 and Bcl - 2 Protein in Epithelial Spuamous cell Carcinoma, Basal Cell Carcinoma and Seborrheic Karatosis |
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| Mao Dongjun,et al.. Expression and Significance of p53 and Bcl - 2 Protein in Epithelial Spuamous cell Carcinoma, Basal Cell Carcinoma and Seborrheic Karatosis[J]. Journal of Qiqihar Medical College, 2001, 22(2): 121-122 |
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| Authors: | Mao Dongjun et al. |
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| Abstract: | Objective To research the expression of P53 and Bcl - 2 in epithelial squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and seborrheic karatosis, then analyse its significance. Methods The expressions of P53 and Bcl - 2 were examined by Immunohistochemical method (S - P) in 12 cases of SCC, BCC and SK respectively. Results 9 cases of SCC and 11 cases of BCC expressed P53. 10 of SCC and 11 of BCC expressed Bcl - 2. Only one of SK expressed P53. The expression rate of P53 in SCC and BCC was remarkable higher than that in SK (P < 0. 01 ). Conclusions The mutation of P53 gene and the expression of Bcl - 2 protein may play an important role in the genesis and progression of malignant tumors of skin |
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| Keywords: | Epithelial tumor Squamous cell carcinoma Basal cell carcinoma Seborrheic karatosis Immunohistochemical method P53 Bcl - 2 |
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