检测血清TRAb水平在甲状腺疾病诊治中的价值

目的:探讨检测血清TRAb水平在甲状腺疾病诊治中的价值.方法:分别检测308例甲状腺疾病患者及正常对照组的血清TRAb水平(采用RRA方法)、FT3,FT4水平及TGAb、TPOAb滴度(采用RIA方法).结果:血清TRAb水平及阳性率:Graves'病发作组、缓解组及桥本氏病组均明显高于正常对照组;Graves'病发作组明显高于缓解组.Graves'病组TRAb水平与血清FT3、FT4水平及桥本氏病组TRAb水平与TGAb、TPOAb滴度间均无相关性.结论:对血清TRAb水平的检测在自身免疫性甲状腺疾病,特别是Graves'病的诊断、治疗中具有重要价值.但其水平的高低却不能反映Graves'病的病情轻重,同时它也是不同于TGAb、TPOAb的另一类自身抗体.

The value of determination of serum TRAb levels in diagnosis and treatment of patients with thyroid disease

Objective:To study the value of measurement of serum TRAb levels in diagnosis and treatment of patients with thyroid disease.Methods:The levels of serum TRAb(by RRA),FT 3?FT 4 and titrations of TGAb,TPOAb(by RIA) were measured in 308 patients with thyroid disease as well as in 50 normal people.Results:The average levels and positive rates of serum TRAb were significantly higher in patients with Graves' disease (including hypertyroid group and remission group) and Hashimoto's disease than those in normal group,and the hypertyroid group were significant higher than the remission group in level and positive rate of TRAb.There were no correlations between serum TRAb levels and FT3,FT4 levels in patients with Graves' disease,and titrations of TGAb,TPOAb in patients with Hashimoto's disease.Conclusion:Serum TRAb level can not reflect the severity of Graves' disease,and TRAb is another auto-antibody different from TGAb,TPOAb,but there is important value in determing the serum TRAb level in diagnosis and treatment of auto-immune thyoid disease,especially to Graves' disease.