河北省恙虫病的血清流行病学研究

目的：对河北省恙虫病疫源地内病例进行血清学分型和抗体动态观察，了解疫源地和非疫源地内人群恙虫病抗体阳性率，初步掌握恙虫病血清流行闰学规律。方法：采集患者病后不同时期的血清标本和疫源地内及非设源地内人群血清标本，用间接免疫荧光法检测恙虫病抗体。结果：27例恙虫病患者均被证实为Gilliam血清型。病后第3d即可出现IgM和IgG抗体，20d至1年IgM和IgG抗体阳性率均为100％，抗体滴度高峰为病后10－19d，之后开始逐渐下降，疫源地内健康人群IgG和IgM抗体阳性率分别为7．70％和4．81％，提示可能存在隐性感染，非疫源地内未发现抗体阳性者。结论：初步阐明恙虫病的血清流行病学特点，在流行区可能存在隐性感染。

Seroepidemiological Study of Tsutsugamushi Disease in Hebei Province

Objective:To obtain Rickettsia tsutsugamushi ( R.t. ) antibody level in patients and healthy population of epidemic area and non-epidemic area, and to get the seroepidemiological pattern of tsutsugamushi disease in Hebei province based on serological typing and dynamic observation.Methods:Serum specimens of different time series after the onset of tsutsugamushi disease were collected from patients. Serum specimens were also collected from healthy population in epidemic area and non-epidemic area. Indirect immunofluorescence were carried out to detect Rt antibody and to identify the serological type. Results:Gilliam serological type was identified in all of the 27 patients. R.t. IgG and IgM antibodies could be detected at 3 days after the onset of disease. And positive rate of both Rt IgG and IgM antibodies were 100% from 20 days to 1 year after the onset of disease. The titers of antibodies reached the peak point at 10-19 days after the onset of disease, and then declined gradually. Positive rates of R.t. IgG and IgM were 7.70 % and 4.81 % in healthy population of epidemic area, respectively. And the antibodies were not detected in healthy population of non-epidemic area. Conclusion:Seroepidemiological pattern of tsutsugamushi disease was clarified primarily. In epidemic area, recessive infection might exist.