急性淋巴细胞白血病80例染色体核型分析及其与疗效的相关性

目的 探讨急性淋巴细胞白血病（ALL）患者的染色体核型特点及其与疗效的关系.方法 采用短期培养法、R显带技术对80例ALL患者骨髓染色体核型进行分析.结果 80例ALL患者中,正常核型53例（66.2％）,异常核型27例（33.8％）,其中,染色体核型结构异常者10例（12.5％）,数目异常者2例（2.5％）,复杂异常15例（18.8％）.按数目畸变分类,＞ 50的超二倍体2例（2.5％）、47～50的超二倍体5例（6.25％）、假二倍体18例（22.5％）、正常二倍体53例（66.25％）、亚二倍体2例（2.5％）、未见近三倍体或近四倍体.正常核型患者疗效优于异常核型患者（x2=19.371,P＜ 0.01）,复杂核型患者疗效差于其他核型患者（x2=9.145,P=0.004）,伴有t（9;22）（q34;q11）患者疗效差于其他核型患者（x2=5.785,P=0.021）.结论 ALL患者的染色体核型异常具有随机性,常见的异常核型为复杂核型和伴有t（9;22）（q34;q11）核型,其疗效均较差.

Karyotype analysis and relationship with the curative effect in 80 patients with acute lymphocytic leukemia

Objective To explore the chromosome kauotype characteristics and the relationship with curative effect in the acute lymphoblastic leukemia （ALL）.Methods The bone marrow cells were collected using a short-term culture method.The R banding technique of chromosome karyotype analysis was used in 80 cases of ALL patients.Results Normal karyotype were found in 53 cases （66.2 %）,and abnormal karyotype in 27 cases （33.8 %）,including structure of chromosome karyotype in 10 cases （12.5 %）,chromosome numerical abnormality in 2 cases （2.5 %）,abnormal complex karyotype in 15 cases （18.8 %）.According to the classification number of distortion,it was found that 〉 50 diploid in 2 cases （2.5 %）,47-50 diploid in 5 cases （6.25 %）,false diploid in 18 cases （22.5 %）,normal diploid in 53 cases （66.25 %）,the diploid in 2 cases （2.5 %）,it did not shown any karyotype was triploid or nearly four times.The curative effect of normal karyotype was superior to that of the abnormal karyotype （x2 =19.371,P 〈 0.01）,that of complex karyotype had poorer than that of other karyotype （x2 =9.145,P =0.004）,and patients accompaning with the t（9;22）（q34;q11） had poorer than that of other karyotype （x2 =5.785,P =0.021）.Conclusions The abnormal chromosome karyotype is random.More common abnormal karyotype is complex karyotype and t（9;22） （q34;q11）,which curative effects are poorer.