热性惊厥患儿烯醇化酶与脑电图检查的临床研究

目的测定热性惊厥(FS)患儿血清中神经元特异性烯醇化酶(NSE)水平与脑电图(EEG)变化,观察NSE与脑损伤的关系,以便指导临床治疗和改善预后。方法选择FS组患儿208例,其中单纯性热性惊厥(SFS)166例,复杂性热性惊厥(CFS)42例,对照组为112名同期我院健康查体儿童。FS组患儿于惊厥发作后24 h内抽取静脉血采用电化学发光法检测血清NSE,对照组标本留取及处理方法相同。FS组患儿分别于发病后第1天和第14天进行EEG检查。结果 FS组患儿血清中NSE水平明显高于健康对照组(P<0.01);CFS组与健康对照组和SFS组比较差异均具有统计学意义(P<0.01)。FS组患儿惊厥发作后第1天EEG异常率为79.8%,其中SFS组78.3%,CFS组85.7%,差异无统计学意义(P>0.05);第14天EEG异常率为24.0%,SFS组仅16.3%,CFS组则54.8%,2组比较差异具有统计学意义(P<0.01)。结论 FS后及时测定血清NSE水平,并结合EEG检查对判断脑损伤程度及预后具有重要价值。

A clinical study of neuron-specific enolase an d electroencephalogram in children with febrile seizures

Objective To detect the levels of neuron-specific enolase（NSE） and change of electroencephalogram （EEG） in serum of febrile seizures （FS）,and observe the relationship between NSE and brain injury to guide clinical treatment and prognosis. Methods From FS group 208 cases of children selected, including simple febrile seizures （SFS） 166 cases and complex febrile seizures （CFS） 42 patients. The control group over the same period 112 cases of child health checkedup in our hospital. NSE was detected by electrochemiluminescence from FS group of children in the seizure within 24 hours venous blood serum, specimens selected and processing method of control group was the same to the FS group. FS group were provided with EEG examination 1 and 14 days after the onset. Results FS group serum NSE level was significantly higher than the control group （P〈0.01）; CFS group and the control group and the SFS group differences were significant （P〈0.01）. FS after seizures in children with EEG abnormalities on day 1 was 79.8%, which SFS group 78.3%, CFS group 85.7%, the difference was not statistically significant （P〉0.05）; the first 14 days of EEG abnormality rate was 24.0%, SFS group only 16.3%, CFS group was 54.8%, the difference was significant （P〈0.01）. Conclusion After to detect FS to detect serum NSE level and combined with EEG examination to determine the degree and prognosis of brain damage is valuable.