特异性微小RNA在恶性黑色素瘤中的研究进展

微小RNA（miRNA）是一类小分子非编码调控性RNA,以细胞及组织特异性方式表达,在维持细胞自身稳态及癌变过程中具有关键性作用.近年来,研究表明许多特异性miRNA与恶性黑色素瘤的发生发展有关.黑色素瘤相关性miRNA通常定位于肿瘤易发生基因扩增及缺失的基因组区域.文章旨在探讨特异性miRNA通过各种途径对不同靶基因的调控从而参与恶性黑色素瘤的生物学进程,并描述了黑色素瘤的治疗现状.

Research progress of individual microRNA in malignant melanoma

microRNAs （miRNAs） are small,non-coding,regulatory RNA molecules group expressed in tissues and cells in specific manner.They are well-known as playing crucial roles in cell homeostasis and carcinogenesis.In recent years,numerou of studys on individual miRNAs or miRNA patterns have been published.These study provided strong evidences that miRNAs might play important roles in malignant melanoma development and progression.Melanoma associated miRNAs often located in genomic regions with frequent gains and losses in tumours.This article focus on some individual miRNAs which involved in melanoma biology,by which may regulate many different target genes by several ways.The current therapy of this disease is also described.