氧化应激、热休克蛋白与免疫功能关系研究进展

氧化应激可诱导热休克蛋白（HSPs）合成的增加，HSPs作为分子伴侣，能保护、调节机体内环境，同时参与固有免疫和适应性免疫。免疫系统通过氧化反应消除病原，同时氧化应激亦可导致免疫系统的损伤，在一定的范围内该损伤可通过HSPs及其他分子机制的作用得到恢复，氧化应激过强可导致病理反应。本文综述报道氧化应激、HSPs和免疫系统三者之间的关系，进而认识这三者在疾病防治过程中的重要作用。

Advance on Relationship among Oxidative Stress,Heat Shock Proteins,and Immunity

Oxidative stress can increase the synthesis of heat shock proteins （HSPs）. Acting as molecular chaperones, HSPs protect and regulate internal homeostasis, and they also participate in innate immunity and adaptive immunity. To remove pathogens, damages may be done to immune system by oxidation reaction hut can be partiaUy repaired by HSPs and other molecular mechanisms. Severe oxidation reaction can also lead to pathological reactions. This review systemically summarized literatures on the relationship among oxidative stress, HSPs, and immunity to reveal their significance in prevention and treatment of diseases.