肠易激综合征患者发病危险因素调查研究

目的：探讨影响肠易激综合征（ IBS）发病的危险因素，为早期预防和干预提供依据。方法采用病例对照的研究方法，将确诊的90例IBS患者作为病例组，同时收集非消化系统疾病患者90例作为对照组；对所有病例进行问卷调查，采用单因素和多因素分析IBS发病的危险因素。结果单因素分析结果显示，酗酒史、喜辛辣食物、喜油炸食物、喜腌制食品、胃肠道感染史、家族性腹泻史、长期服药史、长期紧张状态、失眠、疲劳程度、心情焦虑、心情抑郁、性格内向、敏感性格等因素对IBS存在相关性；多因素分析结果显示：酗酒史（OR＝3．294）、喜辛辣食物（OR＝3．927）、胃肠道感染史（OR＝4．884）、长期服药史（OR＝5．155）、长期紧张状态（OR＝2．656）、失眠（OR＝8．474）、心情焦虑（OR＝2．433）、性格内向（ OR＝1．958）。结论影响肠易激综合征发病的独立危险因素较多，应针对这些高危因素制订有效干预措施。

Risk factors investigation study on irritable bowel syndrome

Objective To explore the risk factors of irritable bowel syndrome （ IBS） , provide basis for early preventing and intervening IBS.Methods With case-control study method, 90 cases of IBS were collected as case group and 90 cases of non-IBS as control group.All of these cases were investigated with self-designed questionnaire , and the risk factors of IBS were screened by single factor and multiple factors analysis methods.Results Single factor analysis result showed that IBS were cor-related with these factors such as excessive drinking, liking spicy food, liking frying food, liking pickle food, history of gastroin-testinal infection, familial diarrhea history, long term overdose, long term stress state, insomnia, extent of tiredness, anxiety mood, depressed mood, introversion character, sensitive character.Multiple factors analysis result showed that the risk factors included in history of excessive drinking （OR=3.294）, liking spicy food （OR=3.927）, history of gastrointestinal infection （OR=4.884）, long term overdose （OR=5.155）, long term stress state （OR=2.656）, insomnia （OR=8.474）, anxiety mood （OR=2.433） and introversion character （OR=1.958）.Conclusion There are many independent risk factors affecting the in-cidence rate of IBS, we should formulate effective intervention measures to aim directly at these high risk factors.