依达拉奉治疗急性重型颅脑损伤的疗效观察

目的观察依达拉奉对急性重型颅脑损伤患者的治疗效果。方法将86例重型颅脑损伤患者（GCS≤8分）随机分为治疗组和对照组。治疗组44例,在常规治疗的基础上加用依达拉奉治疗,对照组42例,给予常规治疗。观察并记录两组患者治疗后第7、14、21天的格拉斯哥昏迷评分（GCS）评分及治疗后3个月时的格拉斯哥预后评分（GOS）。结果两组患者治疗7、14、21 d后GCS评分比较差异均有统计学意义（P〈0.05）;3个月后恢复良好率治疗组（57.14%）明显高于对照组（31.43%）;两组的不良反应比较差异无统计学意义（P〉0.05）。结论依达拉奉有助于缩短急性重型颅脑损伤患者昏迷期,能促进患者神经功能恢复。

Effect of edaravone in the treatment of acute severe head injury

Objective To investigate the efficacy of edaravone and the prognosis of patients with acute severe head injury.Methods Eighty-six cases of acute severe head injury(GCS≤8) patients were randomly divided into two groups,patients in treatment group(n=44) were treated with edaravone on the basis of the routine treatment,patients in control group(n=42) were only given routine treatment.The difference of GCS scores,the consciousness improving rate and clinical prognosis of the patients after three months injured according to GOS scores,were evaluated between the two groups.Results There were significant differences in GCS 7 days and 14 days and 21 days after treatment between the two groups(P<0.05).The rate of good recovery rate was 57.14% in the treatment group,which was significantly higher than that in the control group(31.43%)(P<0.05).Conclusion Edaravone can promote revival of coma in early stage and the recovery of neural function of the patiens with acute severe head injury.