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A case of refractory cutaneous polyarteritis nodosa in a patient with hepatitis B carrier status successfully treated with tumor necrosis factor alpha blockade |
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| Authors: | Takeshi Zoshima Masami Matsumura Yasunori Suzuki Yasushi Kakuchi Ichiro Mizushima Hiroshi Fujii Kazunori Yamada Masakazu Yamagishi Mitsuhiro Kawano |
| Institution: | 1. Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan 2. Research Center for Medical Education, Graduate School of Medicine, Kanazawa University, Takara-machi 13-1, Kanazawa, 920-8640, Japan 3. Division of Cardiology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan |
| Abstract: | We describe a patient with refractory cutaneous polyarteritis nodosa (CPAN) with hepatitis B virus (HBV) carrier status who was successfully treated with tumor necrosis factor alpha (TNF-α) blockade, using etanercept, and we review 5 similar cases. We administered etanercept because of the occurrence of repeated flares despite aggressive therapy. C-reactive protein normalization; prednisolone dose-sparing; and absence of any adverse events, including HBV reactivation with nucleotide analogue administration, or renal dysfunction, have been achieved for 8 months. TNF-α blockade should be considered for intractable CPAN. |
| Keywords: | Cutaneous polyarteritis nodosa Etanercept Hepatitis B Tumor necrosis factor alpha blockade |
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