HLA class I recognition by killer cell Ig-like receptors |
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| Authors: | Long E O Rajagopalan S |
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| Affiliation: | Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA. |
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| Abstract: | Copyright 2000 Academic PressNatural killer (NK) cell activation is regulated by a combination of positive and negative signals coming from repertoires of activating and inhibitory receptors expressed on the surface of each NK cell. Receptors specific for major histocompatibility complex (MHC) class I molecules on target cells inhibit NK effector functions such as cytotoxicity and cytokine production. As reviewed here, the killer cell Ig-like receptor (KIR) family on human NK cells includes receptors with activating as well as inhibitory potential, receptors that have no known ligand, and inhibitory receptors with well-defined specificities for MHC class I such as HLA-B and HLA-C. |
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