| 糖皮质激素受体阻断对大鼠内毒素血症时肠系膜微循环变化的影响 |
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| 引用本文： | 吴建 龚肖崎 张亚霖 徐仁宝. 糖皮质激素受体阻断对大鼠内毒素血症时肠系膜微循环变化的影响[J]. 微循环学杂志, 1992, 2(2): 1-4 |
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| 作者姓名： | 吴建 龚肖崎 张亚霖 徐仁宝 |
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| 作者单位： | 第二军医大学病理生理学教研室，第二军医大学病理生理学教研室，第二军医大学病理生理学教研室，第二军医大学病理生理学教研室 |
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| 摘 要： | 以Ru_(486)阻断糖皮质激素受体(GR),观察了静脉注射内毒素引起的肠系膜微循环变化以及地塞米松预处理的保护作用。实验结果提示:1.内毒素血症时内源性糖皮质激素就有通过其受体介导的微循环保护作用;2.糖皮质激素不仅在应激情况下,即使在正常情况下可能就有抑制白细胞活化作用;3.大剂量糖皮质激素对内毒素休克有一定的防治作用,这一作用至少部分地是由GR所介导的。
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| 关 键 词： | 肠系膜微循环 糖皮质激素受体 内毒素血症 |
The Effect of Blockage of Glucocorticoid Receptor on Mesenteric Microcirculation Change During Endotoxemia in Rats |
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| Wu Jian,. The Effect of Blockage of Glucocorticoid Receptor on Mesenteric Microcirculation Change During Endotoxemia in Rats[J]. Chinese Journal of Microcirculation, 1992, 2(2): 1-4 |
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| Authors: | Wu Jian |
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| Abstract: | With glucocorticoid receptor(GR) blocked by RU_(486), we investigated mesenteric microcirculation change after intraverous injection of endotoxin and protect effect of pretreatment of dexamethasone. The results showed endogenous glucocorticoid had microcirculation protect effect mediated by GR during endotoxemia; glucocorticoid could inhibit WBC activating in stress and normal animals; in treatment of endotoxic shock, large dose of glucocorticoid had benifit mediated partially by GR. |
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| Keywords: | Mesenteric microcirculation Glucocorticoid receptor Endotoxemia |
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