Factors influencing the ablation of atherosclerotic plaque with the argon laser |
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Authors: | Daxin Chen Daosheng Zheng Sihua Zhang Sihong Bao |
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Institution: | (1) Hengyang Medical College, The First Affiliated Hospital, Hengyang City, Human Province, China;(2) Shanghai Second Medical University, Renji Hospital, Shanghai, China |
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Abstract: | This paper describes the ablative effect of argon laser light, delivered fibre optically in vitro, on 234 segments of atherosclerotic
human aorta. Variables such as energy density, type of atheroma and immersion media were taken into account. All irradiated
specimens were subsequently submitted to histological examination and crater volumes in mm3 were derived from micrometer measurements made at light microscopy. Results showed: (1) a linear relationship between energy
dose and crater volume in fibrous atheroma; (2) significantly greater surrounding tissue damage in the higher energy dose
groups; (3) a lower dose response in calcified tissue than in fatty streaks or fibrous atheroma; (4) immersion of tissue in
blood during ablation resulted in a significantly greater dose response than immersion in plasma or saline, and the corresponding
surrounding tissue damage was greatest under blood. Thus, argon laser light is both effective and predictable in response
when ablating atheromatous tissue, and the efficiency of the process depends on the immersion medium. The degree of surrounding
tissue damage depends on the energy dose. |
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Keywords: | Lasers Atherosclerosis Vascular Aorta Plaque Laser angioplasty |
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