| Kentanserin对大鼠心肌缺血-再灌注损伤的影响 |
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| 引用本文： | 张立克,朱盈芬,丁鼎武,娄树纲.Kentanserin对大鼠心肌缺血-再灌注损伤的影响[J].首都医学院学报,1999,20(2):80-82. |
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| 作者姓名： | 张立克 朱盈芬 丁鼎武 娄树纲 |
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| 作者单位： | ：首都医科大学病理生理学教研室 |
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| 摘 要： | 为探讨5-HT2受体与心肌缺血 再灌注损伤的关系,观察5-HT2受体阻断剂kentanserin对心肌缺血 再灌注大鼠室颤及左室内压+dp/dtmax及-dp/dtmax的影响。结果表明,kentanserin可拮抗缺血性心功能障碍和再灌室颤。提示5-HT2受体参与了缺血性心功能障碍和再灌室性心律失常的发生。
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| 关 键 词： | kentanserin 5-HT2受体 心肌缺血-再灌注损伤 |
| 收稿时间： | 1998-06-21 |
| 修稿时间： | 1998-06-21 |
The Influence of Kentanserin on Myocardium Ischemia-repurfusion Injury in Rats |
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| Zhang Like,Zhu Yingfen,Ding Dingwu,Lou Shuguang.The Influence of Kentanserin on Myocardium Ischemia-repurfusion Injury in Rats[J].Journal of Capital University of Medical Sciences,1999,20(2):80-82. |
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| Authors: | Zhang Like Zhu Yingfen Ding Dingwu Lou Shuguang |
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| Institution: | Department of Pathophysiology, Capital University of Medical Sciences |
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| Abstract: | The effects
of kentanserin on ischemia-repurfusion ventricular fibrillation and left ventri-cular
pressure +dp/dtmax and -dp/dtmax in rats were studied in order to
clarify the relationship between the bolcker of 5-HT2 receptor and myocardium
ischemia-repurfusion injury. The results indicated that the kentanserin reduced the change
of ischemic myocardium function and repurfusion ventricular fibrillation. It suggests that
5-HT2 receptor is related to the change of ischemic myocardium function and
repurfusion ventricular arrhthymia. |
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| Keywords: | kentanserin |
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