| 环维黄杨星D升高心肌细胞内游离钙浓度实验研究 |
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| 引用本文： | 梁涛,方泰惠,姚秀娟,蒋永培,梁秉文. 环维黄杨星D升高心肌细胞内游离钙浓度实验研究[J]. 药学与临床研究, 2001, 9(1): 10-12 |
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| 作者姓名： | 梁涛 方泰惠 姚秀娟 蒋永培 梁秉文 |
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| 作者单位： | [1]南京中医药大学，南京210029 [2]第四军医大学，西安710032 |
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| 摘 要： | 观察了环维黄杨星D（CVB－D）对急性分离心肌细胞内游离Ca^2 浓度的影响。应用特异性荧光指示剂Fluo-3/AM负载细胞，用激光共聚焦显微镜检测胞内游离钙的变化。结果表明，CVB－D在10^-5,10^-4mol/L时均可升高心肌细胞内游离钙离子浓度，此作用随剂量增加而增加。因此，CVB－D具有升高心肌细胞内游离钙离子浓度的作用。
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| 关 键 词： | 环维黄杨星D 心肌细胞 游离钙 激光共聚焦显微镜 |
| 收稿时间： | 2000-09-12 |
Experimental Research of Cyclovirbuxine-D Increasing Intracellular Free Ca2+ of Myocardium |
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| Liang Tao,Fang Taihui,Yao Xiujuan,Jiang Yongpei and Liang Bingwen. Experimental Research of Cyclovirbuxine-D Increasing Intracellular Free Ca2+ of Myocardium[J]. Jiangsu Pharmacertical and Clinical Research, 2001, 9(1): 10-12 |
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| Authors: | Liang Tao Fang Taihui Yao Xiujuan Jiang Yongpei Liang Bingwen |
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| Abstract: | The aim is to observe the effect of cyclovirbuxine-D (CVB-D) on intracellular free Ca2+ concentration in acute isolated cardiomyocytes. Intracellular calcium concentration was measured using Ca2+ indicator Fluo-3/AM and laser scanning confocal microscopy. CVB-D was found to increase intracellular free Ca2+ concentration in a dose-dependent manner. So CVB-D could increase cardiomyocytes intracellular free Ca2+ concentration. |
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| Keywords: | Cyclovirbuxine-D myocardium: Ca2+ Laser confocal microscope |
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