Risk of leukaemia and residential exposure to air pollution in an industrial area in Northern Italy: a case-control study |
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| Authors: | Stefano Parodi Irene Santi Claudia Casella Antonella Puppo Fabio Montanaro Vincenzo Fontana |
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| Affiliation: | 1. Institute of Electronics, Computer and Telecommunication Engineering, National Research Council of Italy, Genoa, Italy;2. Clinical Investigation and Documentation, AO Foundation, Dübendorf, Switzerland;3. Liguria Region Tumour Registry, IRCCS AOU San Martino-IST, Genoa, Italy;4. Management and Statistics Unit, Latis Contract Research Organization, Genoa, Italy;5. Unit of Epidemiology, Biostatistics and Clinical Trials, IRCCS AOU San Martino-IST, Genoa, Italy |
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| Abstract: | Leukaemia risk in adult populations exposed to environmental air pollution is poorly investigated. We have carried out a population-based case-control study in an area that included a fossil fuel power plant, a coke oven and two big chemical industries. Information on residential history and several risk factors for leukaemia was obtained from 164 cases, diagnosed between 2002 and 2005, and 279 controls. A higher risk for subjects residing in polluted areas was observed, but statistical significance was not reached (adjusted OR = 1.11 and 1.56 for subjects living in moderately and in heavily polluted zones, respectively, p = 0.190). Results suggest a possible aetiological role of residential air pollution from industrial sites on the risk of developing leukaemia in adult populations. However, the proportion of eligible subjects excluded from the study and the lack of any measure of air pollution prevent definitive conclusions from being drawn. |
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| Keywords: | leukaemia air pollution industrial pollution case-control study environmental risk |
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