无创通气联合特布他林、氨溴索加压雾化吸入治疗COPD疗效观察

目的：探讨双水平气道正压（BiPAP）无创通气联合特布他林、氨溴索加压雾化吸入对重度慢性阻塞性肺疾病（COPD）患者的疗效。方法：人选60例重度COPD患者随机分成试验组及对照组，试验组应用双水平气道正压通气，并联合加压雾化吸人特布他林、氨溴索；对照组应用双水平气道正压通气，比较两者在动脉血气（pH、PaCO2、PaO2）、呼吸频率、心率、无创通气时间、住院天数的差异。结果：试验组、对照组治疗后动脉血气、呼吸频率、心率较治疗前均有变化，试验组较对照组更显著，试验组无创通气时间、住院天数缩短明显优于对照组，差异有统计学意义（P〈O．05）。结论：BiPAP联合特布他林、氨溴索加压雾化吸人治疗重度COPD患者疗效肯定，可以将动脉血气、呼吸频率、心率各项指标有效改善，缩短无创通气时间、住院天数，提高生存质量。

Clinical observation of BiPAP combined with compressing inhalation of terbutaline plus ambroxol of treating COPD patients

Objective： To0bserve the clinicalcffectofBi-level positive airwaypressure（BiPAP） combined with compressing inhalation of terbutaline plus ambmxol in the treatment for acute exacerbation chronic obstructive pulmonary disease （AECOPD） patients. Methods： 60 patients with severe AECOPD were randomly divided into the trial group and the control group. BiPAP was given to patients in both groups,while compressing inhalation of terbutaline plus ambroxol was applied to patients in the trial group. The blood gas analysis,HR and RR before and after treatment as well as days of hospitalization and BiPAP were observed.Results： Blood gas analysis,HR and RR of the patient in two groups were significandy improved （P〈O.05） and the improvement in the trial group was much superior to that in control group with obvious statistic difference（P〈0.05）.The day of staying in hospital and using BiPAP were shorter in the trial group than that in control （P〈O.05）.Condusion- BiPAP combined with compressing inhalation of terbutaline plus ambroxol is better than BiPAP treatment alone in the treatment for severe AECOPD patients, which can improve the quality of life of the patients.