长期家庭氧疗对COPD患者细胞因子及免疫球蛋白影响

目的：观察长期家庭氧疗（LTDOT）对慢性阻塞性肺病（COPD）患者血清中细胞因子及免疫球蛋白的影响.方法：将在我院门诊长期随访的40例COPD患者随机分为两组,常规治疗相同,治疗组于缓解期进行长期家庭氧疗,对照组于缓解期无氧疗.两组患者分别于治疗前及治疗1年后测定血清中细胞因子及免疫球蛋白浓度.结果：COPD患者长期家庭氧疗后血清中细胞因子TGF-β、TNF-α浓度非常显著低于对照组（P＜0.01）,IFN-γ、IL-4浓度明显低于对照组（P＜0.05）,免疫球蛋白浓度明显高于对照组（P＜0.05）.结论：COPD患者长期家庭氧疗可减轻全身性炎症反应,增强机体免疫力.

Long term domiciliary oxygen therapy on the effects of cytokine and immunoglobulin in patients with COPD

Objective： To observe long term domiciliary oxygen therapy （LTDOT） for chronic obstructive pulmonary disease （COPD） effects of serum cytokine and immunoglobulin in patients with. Methods： In outpatient Department of our hospital＇s long-term follow-up of 40 cases of COPD patients were randomly divided into two groups, the same as regular treatment, treatment group in the remission stage of long term oxygen therapy in remission without oxygen therapy in the control group. Before each of the two groups of patients in treatment and after 1 year of treatment in the determination of serum cytokine and immunoglobulin levels. Results：Long term oxygen therapy in patients with COPD in serum cytokine TGF-γ, TNF-α concentration is significantly lower than the control group （P〈0.01）, IFN-γ, IL-4 concentrations significantly lower than the control group （P〈0.05）,immunoglobulin concentration is significantly higher than the control group （P〈0.05）.Conclusion：Long-term oxygen therapy in patients with COPD can alleviate the systemic inflammatory response syndrome, enhance the body immunity.