牙齿缺失与上消化道肿瘤关系前瞻性研究

[目的]探讨牙齿缺失与食管癌、贲门癌、胃癌发病的关系.[方法]采用前瞻性队列的研究方法.研究对象为1986～1991年林州市营养干预试验研究中的普通人群组,随访11年,观察牙齿缺失与食管癌、贲门癌、胃癌发生的关系,资料采用SPPSSl0.0多因素非条件Logistic回归分析.[结果]男性牙齿缺失与食管癌、贲门癌发病有统计学关联,相对危险度(RR)分别为1.265(95%CI=1.115～1.435,P=0.000);1.170(95%CI=1.009～1.356),P=0.037.女性牙齿缺失与胃癌发病有统计学关联,RR值为1.470(95%CI=1.042～2.074),P=0.027.经调整年龄、吸烟、体质指数、家族史等混杂因素后,男性牙齿缺失增加食管癌发病、女性牙齿缺失增加胃癌发病的危险性.牙齿缺失与上消化道肿瘤发病存在剂量-反应关系.[结论]在林州市男性牙齿缺失增加食管癌、贲门癌发病的危险,女性牙齿缺失增加胃癌发病的危险.

Prospective Study on the Relationship Between Tooth Loss and Upper Gastrointestinal Cancer

To investigate the relationship between tooth loss and the occurrence of esophageal carcinoma,cardia carcinoma and stomach cancer.All the persons who had taken part in the General Population Study, Linxian Nutrition Intervention Trails were followed up for 11 years, to investigate the relationship between tooth loss and the occurrence of esophageal carcinoma,cardia cancer and stomach cancer by prospective study.The data were analyzed by non-conditional Logistic regression by SPSS10.0 software.For male,teeth loss significantly increased the risk of esophageal and cardia carcinoma,the relative risk (RR) was 1.265 (95% CI=1.115~1.435,P=0.000) and 1.170 (95% CI=1.009~1.356,P=0.037) respectively.For female,teeth loss had significantly increased risk of stomach cancer (RR=1.470,95%CI=1.042~2.074,P=0.027).After adjusting the confounding factors such as age,smoking,body mass index(BMI) and family history of cancer, tooth loss increased risk of esophageal cancer in male and gastric cancer in female.There were dose-response relationship between the number of tooth lose and esophageal,gastric cancer.[Conclusions]Teeth loss significantly increases risk of esophageal and cardia carcinoma in males and increase risk of stomach cancer in female in Linxian.