| 纳洛酮降低脑梗死患者血浆黏附分子表达水平的探讨 |
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| 引用本文： | 周秀丽,张丽娟. 纳洛酮降低脑梗死患者血浆黏附分子表达水平的探讨[J]. 中国实用神经疾病杂志, 2008, 11(9): 59-60 |
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| 作者姓名： | 周秀丽 张丽娟 |
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| 作者单位： | 1. 河南信阳市中心医院神经内科,信阳,464000
2. 河南长葛市公安局刑警大队技术中心,长葛,461500 |
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| 摘 要： | 目的 探讨纳洛酮(naloxone)降低血浆中黏附分子sICAM-1、VCAM-1的表达.方法 应用酶联免疫吸附法测定15例脑梗死患者急性期和恢复期血浆中sICAM-1、VCAM-1含量,并与12例对照组患者血浆中sICAM-1、VCAM-1含量作对照观察.结果 对照组有较高的黏附分子表达水平,纳洛酮治疗组黏附分子表达水平显著低于对照组(P<0.05).结论 纳洛酮可能通过减轻脑梗死后局部的炎性反应,从而起到脑保护作用.
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| 关 键 词： | 纳洛酮 脑梗死 黏附分子 |
Exploration on the decreased expression of adhesion molecules in blood plasma of cerebral infraction patients by naloxone |
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| Zhou Xiuli,Zhang Lijuan. Exploration on the decreased expression of adhesion molecules in blood plasma of cerebral infraction patients by naloxone[J]. Chinese Journal of Practical Neruous Diseases, 2008, 11(9): 59-60 |
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| Authors: | Zhou Xiuli Zhang Lijuan |
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| Affiliation: | Zhou Xiuli,Zhang Lijuan.Department of Neurology,Xinyang Central Hospital,Xinyang 464000,China |
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| Abstract: | Objective To study the decrease of the expression of sICAM-1,VCAM-1 in blood plasma of cerebral infraction patients by naloxone.Methods A prospective analysis was performed on blood plasma samples in 15 patients with cerebral infraction in acute stage and convalescence and 12 control patients by using quantitative enzyme-linked immunosorbent assays for sICAM-1,VCAM-1.Results The levels of sICAM-1 in blood plasma of patients with cerebral infraction in acute stage and convalescence were significantly higher than those of control group(P<0.01);The levels of VCAM-1 were found to be elevated in blood plasma of patients compared with that in the controls(P<0.05).Conclusion Naloxone may have the brain protective effects by relieving the inflammation in fuci after cerebral infraction. |
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| Keywords: | Naloxone Cerebral infraction Adhesion molecule |
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