A Preliminary Report on Autologous Bone Marrow Transplantation for the Treatment of Advanced Non-Hodgkin's Lymphoma |
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| Authors: | HATTORI, KEN-ICHI HARADA, MINE YOSHIDA, TAKASHI ISHINO, CHIZUKO FUNADA, HISASHI KODO, HIDEKI MORI, TAKAO MATSUE, KOSEI SHIOBARA, SHINTARO ODAKA, KAZUAKL OHTAKE, SHIGEKI TESHIMA, HIROFUMI KONDO, KUNIO YAMAMURA, MAYUMI NAKAO, SHINJI UEDA, MIKIO NAKAMURA, SHINOBU |
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| Affiliation: | Kanazaxva University Bone Marrow Transplant Team, Department of Medicine and Blood Transfusion Service, Kanazawa University School of Medicine Kanazawa, Ishikawa |
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| Abstract: | Four patients with advanced non-Hodgkin's lymphoma of unfavorablehistology were treated with marrow-lethal doses of cyclophosphamide(CY) and total body irradiation (TB1) followed by the infusionof cryopreserved autologous marrow. All four patients showedengraftment after autologous bone marrow transplantation andachieved complete remission (CR). Three of them, however, developedrelapse in 1.7, 12.9 and 14.5 mo respectively after the transplantation.The other patient has survived in drug-free CR for more than16.6 mo. There was no treatment-related death although therewere some tolerable complications. These data suggest that theCY-TBI regimen may be effective in inducing CR in patients withadvanced non-Hodgkin's disease but it does not contribute topreventing relapse. |
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