斑点追踪技术与组织多普勒技术对不同年龄正常人左心室舒张功能的评价

目的应用斑点追踪技术测得解旋率(UntwR)与组织多普勒技术(DTI)评价不同年龄段正常人左心室的舒张功能,并探讨两者的相关性。方法健康体检者94例,按年龄分为青年组(18～45岁)、中年组(46～64岁)和老年组(65～79岁)及高龄组(≥80岁)。取胸骨旁左心室心尖和心底短轴切面二维灰阶图像,用EchoPAC软件行脱机分析并计算UntwR;应用脉冲多普勒测定二尖瓣口血流早期充盈峰峰值速度(E),应用DTI技术测定二尖瓣环室间隔侧舒张早期峰值速度e’,计算两者比值E/e’。结果随年龄增加,UntwR测值逐渐减低,4组间比较差异均有统计学意义(P均0.05);UntwR与E/e’及e’相关系数r分别是0.54,0.53(P均0.01)。结论 UntwR与目前常用的评价左心室舒张功能的多普勒指标相关性良好,UntwR可无创评价由年龄引起的正常人左心室舒张功能的变化。

Age-related changes in left ventricular diastolic function assessed by speckle tracking imaging and Doppler tissue imaging

Objective To determine if the degree of untwisting rate （UntwR） is related to estab- lished parameters of diastolic function. Methods Ninety-four healthy subjects were classified into four groups by age, a group of 19-45 years old,a group of 46-64 years old, a group of 65-79 years old and a group of I〉80 years old. Basal and apical left ventricular（LV） short-axis images were achieved in the total population. The peak early （E） transmittal filling velocities, mitral septal annular tissue Doppler velocity （ e＇ ） were measured. The ratio of E/e＇ and UntwR were calculated. Results Along with an increase of ages, UntwR decreased significantly （ P 〈 0.05 ） and the difference had no significant difference among the 4 groups （P 〉 0.05）. Both E/e＇ and e＇ were correlated with UntwR （ P 〈 0.01 for both）. Conclusions The UntwR is related to the established echocardiographic measures of diastolic function and the age-related changes of left ventricular diastolic function could be evaluated by non-invasive speckle tracking imaging（STI）.