Hyperglycemia-related pathophysiologic mechanisms and potential beneficial actions of melatonin |
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Authors: | Korkmaz Ahmet Topal Turgut Oter Sukru Tan Dun-Xian Reiter Russel J |
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Institution: | Gulhane Askeri Tip Akademisi, Fizyoloji Anabilim Dali, 06018 Ankara, Turkey. |
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Abstract: | Chronically-elevated blood glucose initiates a harmful series of processes in which toxic reactive species play crucial roles. Oxidative as well as nitro-oxidative stress is harmful for virtually all biomolecules including lipids, proteins and DNA. Such pathophysiologic mechanisms eventually results in cellular dysfunction, apoptosis or necrosis. Melatonin is a multifunctional indolamine which counteracts several pathophysiologic steps and displays significant beneficial effects against hyperglycemia-induced cellular toxicity. These are related to melatonin's antioxidative, anti-inflammatory and possibly epigenetic regulatory properties. Current knowledge encourages using this non-toxic indolamine either as a sole treatment or in conjunction with other treatments for inhibition of the biohazards of hyperglycemia. |
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