同步放化疗联合射频消融术治疗非小细胞肺癌的临床观察

目的:探讨同步放化疗联合射频消融术治疗非小细胞肺癌的临床疗效.方法:将40例非小细胞肺癌患者随机分为放化疗联合射频消融术(综合组,n=19)和单纯放化疗(对照组,n＝21).化疗采用常规EP方案,放疗为适形放疗.分别于治疗完成后3、6个月和1、2、3年复查,从KPS、肿瘤大小、生存率对患者进行临床评价,研究综合治疗的临床疗效.结果:综合治疗的KPS评分及肿瘤体积减小明显高于对照组,且差异有统计学意义,P＜0.05.有效率(CR+PR)综合组为78.9％,而对照组为42.9％.综合组6个月、1、2和3年生存率分别约为100.0％(19/19)、89.4％ (17/19)、73.6％(14/19)和57.9％(11/19);对照组分别为100％(21/21)、76.2％(16/21)、47.6％(10/21)和28.6％ (6/21),3年生存率差异有统计学意义,P=0.03.结论:放化疗联合射频消融治疗非小细胞肺癌能显著增强疗效,提高患者生存率,是目前较理想、值得临床广泛推广的一种综合治疗方法.

Combination of synchronization chemoradiotherapy and CT-guided radiofrequency ablation for treatment of non-small cell lung cancer

OBJECTIVE:To discuss the clinical curative effect combination of synchronization chemoradiotherapy and CT-guided radiofrequency ablation for treatment of non-small cell lung cancer.METHODS:Forty non-small cell lung cancer patients were involved in this study.Nineteen recieved combination of synchronization chemoradiotherapy and CT-guided radiofrequency ablation(the synthesis group),and 21 recieved the synchronization chemoradiotherapy(the control group 21).The chemotherapy was the conventional EP plan,and the radiotherapy was three-dimensional conformal radiotherapy.The patients were asked to come back to hospital for check 3 months,6 months,1 year,2 years and 3 years after treatment respectively.And the clinical evaluation were performed from KPS,tumor size and survival rate.RESULTS:KPS grading and the tumor volume reduce in synthesis group were higher than the control group obviously,and had the remarkable statistics significance(P<0.05).Effectiverates(CR+PR) were 78.9% and 42.9%.Six months,1-,2-and 3-years survival rates were 100%(19/19),89.4%(17/19),73.6%(14/19),57.9%(11/19) in synthesis group;In the control group,they were 100%(21/21),76.2%(16/21),47.6%(10/21),28.6%(6/21);Three year survival rates had the remarkable statistics significance(P=0.03).CONCLUSION:Combination the synchronization chemoradiotherapy and CT-guided radiofrequency ablation for the treatment of non-small cell lung cancer,can obviously strengthen the treat ment effect,raise the patient survival rate.It is worth clinical widespread.