VEGF-C和VEGF-D在胃癌组织中的表达与淋巴结转移的关系 |
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引用本文: | 王文欢,伍仁毅,孙国瑛,李新华,袁伟建,唐丽安. VEGF-C和VEGF-D在胃癌组织中的表达与淋巴结转移的关系[J]. 中南大学学报(医学版), 2010, 35(4): 335. DOI: 10.3969/j.issn.1672-7347.2010.04.009 |
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作者姓名: | 王文欢 伍仁毅 孙国瑛 李新华 袁伟建 唐丽安 |
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作者单位: | 中南大学1.湘雅医院消化内科, 长沙 410008; 2.湘雅医学院生理学系, 长沙 410078 |
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摘 要: | 目的:探讨胃癌患者血管内皮生长因子C和D(vascular endothelial growth factor-C and-D, VEGF-C and VEGF -D)在胃癌组织中的表达及其与肿瘤淋巴结转移的关系。方法:应用免疫组织化学SABC法及Real-time PCR法检测32例胃癌组织和32例正常胃组织中VEGF-C,VEGF-D蛋白及其mRNA的表达。 结果:胃癌组织VEGF-C和VEGF-D表达明显高于正常胃组织(P<0.01), 其中淋巴结转移组VEGF-C,VEGF-D的表达与淋巴结未转移组间差异有统计学意义(P<0.05)。VEGF-C和VEGF-D在胃癌组织中的表达与淋巴结转移有关(P<0.01)。VEGF-C和VEGF-D的表达在高分化癌、中分化癌和低分化癌中的差别有统计学意义(P<0.05)。VEGF-C和VEGF-D 在胃癌细胞中的表达与患者年龄、 性别和淋巴结远处转移无关(P>0.05)。结论:胃癌细胞非摄入性高表达的VEGF-C和VEGF-D与淋巴结转移密切相关,可作为评估胃癌患者预后的重?慰贾副辍?
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关 键 词: |   胃癌 血管内皮生长因子C 血管内皮生长因子D 淋巴结转移 |
Expression of VEGF-C and VEGF-D in gastric carcinoma and its relationship with lymph node metastases |
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Affiliation: | 1.Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008; 2.Department of Physiology,Xiangya School of Medicine, Central South University, Changsha 410078, China |
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Abstract: | ObjectiveTo explore the expression of vascular endothelial growth factor (VEGF) C and D in gastric cancer and its relationship with tumor angiogenesis and lymph node metastasis.MethodsImmunohistochemistry(SABC) and real-time PCR were used to detect the expression of VEGF-C, VEGF-D protein and mRNA in 32 gastric cancer tissues and 32 normal gastric tissues.ResultsThe positive expression rate of VEGF-C and VEGF-D in gastric cancer tissue was significantly higher than that of normal gastric tissues (P<0.01), the expression of VEGF-C and VEGF-D in the gastric cancer group and the lymph node metastasis group were significantly different (P<0.05). The expression of VEGF-C and VEGF-D in gastric carcinoma was positively correlated with lymph node metastasis (P<0.01), the expression of VEGF-C and VEGF-D in well-differentiated carcinoma, moderately differentiated carcinoma and poorly differentiated carcinoma was statistically different (P<0.05). VEGF-C and VEGF-D expressions in gastric cancer cells were not related to the patient’s age, sex, and lymph node distant metastasis (P>0.05). ConclusionThe non-intake high expression of VEGF-C and VEGF-D in gastric cancer cells is closely related to lymph node metastasis. They serve as the important reference indicator to assess the prognosis in gastric cancer patients. |
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Keywords: | gastric cancer vascular endothelial growth factor-C vascular endothelial growth factor-D lymph node metastases, |
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