| 口腔粘膜鳞癌组织中P53和nm23蛋白的表达分析 |
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| 引用本文： | 葛明华,王可敬,张谷.口腔粘膜鳞癌组织中P53和nm23蛋白的表达分析[J].中国耳鼻咽喉头颈外科,2001,8(2). |
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| 作者姓名： | 葛明华 王可敬 张谷 |
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| 作者单位： | 1. 杭州浙江省肿瘤医院头颈外科
2. 浙江省肿瘤医院病理科 |
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| 摘 要： | 目的 :研究口腔粘膜鳞癌组织中 P5 3和 nm2 3蛋白的表达及意义。方法 :采用免疫组化方法检测 10 0例口腔粘膜鳞癌组织中 P5 3和 nm2 3蛋白的表达状况。结果 :口腔粘膜鳞癌组织中 P5 3蛋白的阳性表达率为 5 8.0 % ,nm2 3蛋白的阳性表达率为 40 .0 % (P<0 .0 5 )。颈淋巴结有转移者较无转移者 P5 3蛋白阳性表达率高 ,而 nm2 3蛋白阳性表达率低。结论 :P5 3 和 nm2 3蛋白表达状况与口腔粘膜鳞癌颈淋巴结转移有关。
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| 关 键 词： | 口腔肿瘤(Mouthneoplasms) 癌(Carcinoma) 基因(Genes |
Expressions of p53 and nm23 proteins in oral squamous cell carcinoma |
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| Ge Minghua,Zhang Gu,Wang Kejing.Expressions of p53 and nm23 proteins in oral squamous cell carcinoma[J].Chinese Archives of Otolaryngology-Head and Neck Surgery,2001,8(2). |
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| Authors: | Ge Minghua Zhang Gu Wang Kejing |
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| Institution: | Dr Ge Minghua |
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| Abstract: | Objective:To investigate the expressions of P53and nm23 proteins in cancer tissue of patients with oral squamous cell carcinoma.Methods:There were 57 males and 43 females,ranging in age from 35 to 75 years old.The clinical stages were T1 10,T2 29,T3 56 and T4 5;pathologic classifications were high differentiation in 74,medial and low differentiation in 26;lymph node metastasis in 56,no metastasis in 44.The expressions of P53 and nm23 proteins were detected by immunohistochemical technique.Results:The expressions rates of P53and nm23 proteins were 58.0%(58/100) and 40.0%(40/100) respectively (P＜0.05)in cancer tissue of patients with oral squamous cell carcinoma.The expressions rates of P53and nm23 were 71.5%(40/56)and 28.6%(16/56)in group of patients with node lymph node metastasis;40.9%(18/44)and 54.5%(24/44) in group of patients with negative metastasis respectively.Conclusion:Lymph node metastasis might be correlated with high level expression of P53 protein and low level expression of nm23 protein in patients of oral squamous cell carcinoma. |
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| Keywords: | Mouth neoplasms) (Carcinoma) (Genes) |
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