儿科常用清热解毒类中药注射剂不良反应文献计量分析

采用回顾性文献计量分析的方法,对2007年1月到2012年5月CNKI数据库中有关清热解毒类中药注射剂导致儿童不良反应（ADR）的文献进行统计分析。清热解毒类中药注射剂导致儿童ADR的发生率较高,其中以清开灵和双黄连注射液表现尤为突出。儿童ADR类型以皮肤及其附件损害最为常见,其次为全身反应,再次为消化系统反应。导致儿童ADR的相关因素有小儿特殊的生理病理特点、中药注射剂的质量和制备工艺以及中药注射剂的临床不合理应用。从药品生产、国家监测和临床用药过程等方面提出减少儿童ADR的措施。

Bibliometric analysis on adverse drug reaction of traditional Chinese medicine injections with heat clearing and detoxicating in pediatrics

By retrospective bibliometric analysis,statistical analysis for the literature of adverse drug reaction（ADR） of traditional Chinese medicine（TCM） injections with the heat clearing and detoxicating in pediatrics based on the CNKI database from January 2007 to May 2012 was carried out.The TCM injections with the heat clearing and detoxicating result in the higher incidence of ADR in children,particularly Qingkailing and Shuanghuanglian Injections.The most common type of ADR in children is skin and its accessories damage,followed by the whole body reaction and the digestive system reaction.ADR in children relates to the pediatric special physiological and pathological characteristics,quality and preparation technology of TCM injections,and unreasonable clinical use of.TCM injections.The measures to reduce ADR in the admininstration for the children have been put forward in pharmaceutical production,state monitoring,and clinical application process and other aspects.