Gemcitabine radiosensitizes multiple myeloma cells to low let, but not high let, irradiation. |
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Authors: | Stéphane Supiot Francois Thillays Emmanuel Rio Sébastien Gouard Alfred Morgenstern Frank Bruchertseifer Marc-André Mahé Jean-Fran?ois Chatal Fran?ois Davodeau Michel Chérel |
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Affiliation: | Département de Recherche en Cancérologie, Université de Nantes, Nantes, France. |
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Abstract: | The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and high-LET particles (alpha-RIT (213)Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1, RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but did not radiosensitize any cell line when combined with high-LET. |
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