不同剂量碘普罗胺对老年患者肾功能的影响

目的：了解不同剂量的低渗性非离子型造影剂碘普罗胺（Iopromide）对老年病人肾功能的影响。方法：31例无肾病史、术前肾功能正常的患者依据接受造影剂的剂量不同分为两组。通过在术后第1天、5天测定血清尿素氮（BUN）、血清肌酐（Scr）及肌酐清除率（Ccr），观察使用非离子型造影剂碘普罗胺后患者的肾功能变化。结果：造影前及后1d，5d，两组病人间BUN，Scr和Ccr水平差异性均无显著（P〉0．05）。术后1d时，两组病人均出现Scr轻度升高、Ccr轻度降低，5d时，则恢复到造影前水平。全部病例均无急性肾功能衰竭发生。结论：一次294ml以内剂量的非离子型造影剂碘普罗胺对老年病人是相对安全的，应用后Scr，Ccr的轻度改变，在5d内恢复至造影前水平，且在一定剂量范围内与造影剂剂量间无显著相关性。

A Study on the Effect of Different Dosages of Iopromide on Renal Function in Old Patients

Objective: To investigate the effect of iopromide, a kind of low osmolar and nonionic contrast media, on renal function in old patients. Methods: 31 old patients who would accept angiography and other percutaneous vascular intervention operations were selected and were divided into two groups according to the low or high dosage of contrast media. The renal function of these patients were normal before accepting Iopromide. Their serum creatinine (Scr), creatinine clearance rate (Ccr) and blood urine nitrogen were monitored on the first and fifth days after accepting Iopromide. Evaluation of renal function changes of these old patients was carried out. Results: After the use of iopromide, no remarkable difference of Scr or Ccr was observed in the two groups. All patients'Scr was elevated and Ccr decreased slightly on the first day, but the level retuned to normal on the fifth day. Acute renal function failure was not found in these patients. Conclusions: The changes of Scr and Ccr after the use of iopromide do not relate with the dosages of contrast media. The dosage of 294 ml once is comparatively safe for old patients.