| STAT3、MRP、LRP在肺腺癌A549及A549/CARP耐卡铂细胞株中的表达及关系的研究 |
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| 引用本文： | 王鸿程,李艳萍,曹兵. STAT3、MRP、LRP在肺腺癌A549及A549/CARP耐卡铂细胞株中的表达及关系的研究[J]. 泸州医学院学报, 2006, 29(4): 295-297 |
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| 作者姓名： | 王鸿程 李艳萍 曹兵 |
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| 作者单位： | 泸州医学院附属医院呼吸内科,四川,泸州,646000 |
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| 摘 要： | 目的:探明STAT3与肺腺癌细胞多药耐药之间的关系.方法:采用免疫组化法测定A549及A549/CARP耐卡铂细胞株中STAT3、LRP、MRP蛋白表达情况.结果:STAT3在A549组、A549/CARP组中阳性细胞数无显著性差异(t=1.519,P＞0.05);LRP、MRP在A549组、A549/CARP组中阳性细胞数有显著性差异(t=3.350,P＜0.01)(t=3.747,P＜0.01);STAT3、LRP、MRP之间表达均无相关性(r=0.061,P＞0.05).结论:STAT3并未直接参与介导肺腺癌的多药耐药性;LRP、MRP均参与了诱导肺腺癌的耐药,但二者之间无相关性;STAT3信号传导途径与LRP、MRP蛋白的激活机制可能无关.
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| 关 键 词： | A549 A549/CARP STAT3 MRP LRP |
| 文章编号： | 1000-2669(2006)4-0295-03 |
| 收稿时间： | 2006-01-06 |
| 修稿时间： | 2006-01-06 |
THE RESEARCH OF THE EXPRESSION AND RELATIONSHIP OF STAT3、MRP、LRP IN LUNG ADENOCARCINOMA A549 AND CARP-RESISTANT A549(A549/CARP) |
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| Wang Hongcheng, et al. THE RESEARCH OF THE EXPRESSION AND RELATIONSHIP OF STAT3、MRP、LRP IN LUNG ADENOCARCINOMA A549 AND CARP-RESISTANT A549(A549/CARP)[J]. Journal of Luzhou Medical College, 2006, 29(4): 295-297 |
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| Authors: | Wang Hongcheng et al |
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| Affiliation: | Department of Respiratory Medicine,the Affiliated Hospital of Luzhou Medical College |
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| Abstract: | |
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| Keywords: | A549 A549/CARP STAT3 MRP LRP |
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