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Secreted Wnt Antagonists During Eradication of Cytomegalovirus Infection in Solid Organ Transplant Recipients |
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| Authors: | T Ueland H Rollag A Hartmann A G Jardine A Humar A E Michelsen A A Bignamini A Åsberg P Aukrust |
| Institution: | 1. Research Institute of Internal Medicine, Oslo University Hospital, , Rikshospitalet, Oslo, Norway;2. Faculty of Medicine, University of Oslo, , Oslo, Norway;3. Department of Microbiology, Oslo University Hospital, , Rikshospitalet, Oslo, Norway;4. Department of Organ Transplantation, Gastroenterology and Nephrology, Section for Nephrology, Oslo University Hospital, , Rikshospitalet, Oslo, Norway;5. Institute of Cardiovascular and Medical Sciences, University of Glasgow, , Glasgow, UK;6. Department of Medicine, University of Alberta, , Edmonton, Canada;7. School of Specialization in Hospital Pharmacy, University of Milan, , Milan, Italy;8. Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, , Oslo, Norway;9. Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, , Rikshospitalet, Oslo, Norway |
| Abstract: | We evaluated secreted wingless (Wnt) modulators during cytomegalovirus (CMV) infection in solid organ transplant recipients (SOTr). The major findings were: (i) Plasma levels of Dickkopf‐1 (DKK‐1) were significantly lower in patients with CMV DNAemia above lower level of quantification at baseline. (ii) Receiver operating characteristic analysis indicated that low DKK‐1 and increased secreted frizzled related protein‐3 levels were predictors of poor virological outcomes during follow‐up. Our findings demonstrate an imbalanced pattern of circulating secreted Wnt modulators in SOTr with poor virological outcomes following treatment for CMV disease, and may suggest a role for dysregulated Wnt signaling on viral pathogenesis during CMV infection. |
| Keywords: | CMV infection solid organ transplant recipients virological outcome Wnt signaling |