Structure–Activity Relationship of Terpenes with Anti‐Inflammatory Profile – A Systematic Review |
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| Authors: | Marilia Trindade de Santana Souza Jackson Roberto Guedes da Silva Almeida Adriano Antunes de Souza Araujo Marcelo Cavalcante Duarte Daniel Pens Gelain José Cláudio Fonseca Moreira Marcio Roberto Viana dos Santos Lucindo José Quintans‐Júnior |
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| Affiliation: | 1. Department of Physiology, Federal University of Sergipe, , S?o Cristov?o, SE, Brazil;2. College of Pharmaceutical Sciences, Federal University of S?o Francisco Valley, , Petrolina, PE, Brazil;3. Department of Pharmacy, Federal University of Sergipe, , S?o Cristov?o, SE, Brazil;4. Department of Biochemistry, Federal University of Rio Grande do Sul, , Porto Alegre, RS, Brazil |
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| Abstract: | Inflammation is a complex biological response that in spite of having available treatments, their side effects limit their usefulness. Because of this, natural products have been the subject of incessant studies, among which the class of terpenes stands out. They have been the source of study for the development of anti‐inflammatory drugs, once their chemical diversity is well suited to provide skeleton for future anti‐inflammatory drugs. This systematic review reports the studies present in the literature that evaluate the anti‐inflammatory activity of terpenes suffering any change in their structures, assessing whether these changes also brought changes in their effects. The search terms anti‐inflammatory agents, terpenes, and structure–activity relationship were used to retrieve English language articles in SCOPUS, PUBMED and EMBASE published between January 2002 and August 2013. Twenty‐seven papers were found concerning the structural modification of terpenes with the evaluation of anti‐inflammatory activity. The data reviewed here suggest that modified terpenes are an interesting tool for the development of new anti‐inflammatory drugs. |
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