Right ventricular function in patients with chronic obstructive pulmonary disease |
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Authors: | H Seibold E Henze J Kohler J Roth A Schmidt W Adam |
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Institution: | (1) Sektion Kardiologie, Pulmonologie, Angiologie, Universität Ulm, Germany;(2) Abteilung Nuklearmedizin, Universität Ulm, Germany |
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Abstract: | Summary Simultaneous right heart catheterization and radionuclide ventriculography were performed in 27 patients with a wide range of chronic obstructive pulmonary disease. Central hemodynamics and radionuclide studies were done at rest and during exercise. In the resting state the right ventricular ejection fraction (RVEF) was in the normal range (43.3±6%). During exercise a significant (p<0.001) decrease of RVEF to 38.8±6.7% occurred. The pumonary artery mean pressures were 19.9±3.8 at rest. During exercise a significant (p<0.001) increase to 41±9.8 mm Hg occurred. There was a linear relationship between pulmonary pressures and RVEF during exercise in patients with pulmonary artery pressures not exceeding 35 mm Hg. In patients with right ventricular end-diastolic wall thickness 6 mm a curvilinear relationship between these parameters could be observed with a flattening of the curve at higher pressures (>35 mm Hg) and lower ejection fractions (<35% RVEF). Radionuclide venticulography cannot substitute for right heart catheterization. Echocardiography is useful for interpretation of right ventricular ejection fractions in advanced chronic obstructive pulmonary disease.Abbreviations CI
Cardiac index (l/min/m2)
- CO
Cardiac output (l/min)
- COPD
Chronic obstructive pulmonary disease
- FEV1
Forced expiratory volume in the first second (ml)
- HR
Heart rate (B/min)
- PAd
Pulmonary artery diastolic pressure (mm Hg)
- PAP
Pulmonary artery mean pressure (mm Hg)
- PAs
Pulmonary artery peak pressure (mm Hg)
- PVR
Pulmonary vascular resistance (dyn·s·cm–5)
- PwP
Pulmonary capillary wedge pressure (mm Hg)
- RAP
Right arterial pressure (mm Hg)
- Raw
Airway resistance (cm H2/l/s)
- RNV
Radionuclide ventriculogram
- RV
Residual volume (l)
- RVEF
Right ventricular ejection fraction (%)
- RVEDVI
Right ventricular enddiastolic volume index (ml/m2)
- RVEDVI
SVI RVEF (ml/m2)
- RVESVI
Right ventricular endsystolic index (m2/m2)
- SVI
Stroke volume index (ml/m2)
- TLC
Total lung capacity (l)
- VC
Vital capacity (l) |
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Keywords: | Chronic bronchitis Right heart disease |
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