低剂量氨茶碱治疗小儿毛细支气管炎疗效分析

目的探讨低剂量氨茶碱治疗毛细支气管炎的疗效。方法将71例毛支患儿随机分为常量氨茶碱组和低剂量氨茶碱组,观察其对毛支的疗效及相关副作用。结果常量氨茶碱组和低剂量氨茶碱组显效率分别为61.1%、54.5%,总有效率分别为91.7%、87.8%,两组比较无显著性差异(P>0.05);相关副作用发生率常量氨茶碱组(36.8%)明显高于低剂量氨茶碱组(9.0%)(P<0.01)。结论低剂量氨茶碱治疗毛细支气管炎安全有效,副作用小。

Effects of low-dose aminophlline on bronchiolitis in children

Objective: To investigate the clinical effects of low-dose aminophylline on children with bronchiolitis. Methods: 71 bronchiolitis were assigned randomly into two groups: normol-dose aminophylline group (38 cases) and low-dose aminophylline group (33 cases). The low-dose aminophylline group were mainlined 1.5 ~ 2 mg/kg first,and then were administered orally 3 mg/kg, three times a day. The normol-dose aminophylline group were given 3 ~ 4 mg/kg and 5 mg/kg. The clinic effects and side effects were compared between the two groups after 3 days. Results: The clinical effects of two groups were no significant difference (P > 0.05). The side effects in low-dose aminophylline group were much less than that in normol-dose aminophylline group (P < 0.01). Conclusion: Low-dose aminophlline is effective and safe in treating the bronchiolitis.