| 橙皮苷对STZ－糖尿病大鼠周围神经结构和功能的影响 |
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| 引用本文： | 王新嘉,张辉,何国芬,张志利. 橙皮苷对STZ－糖尿病大鼠周围神经结构和功能的影响[J]. 中国病理生理杂志, 1996, 0(6) |
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| 作者姓名： | 王新嘉 张辉 何国芬 张志利 |
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| 作者单位： | 山西医科大学第二附属医院内科，山西医科大学第一附属医院内分泌科 |
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| 摘 要： | 本实验在链脲菌素（ｓｔｒｅｐｔｏｚｏｃｉｎ，ＳＴＺ）导致的糖尿病大鼠观察了橙皮苷（ＨＥ）对周围神经非酶糖基化作用、运动神经传导速度（ＭＮＣＶ）及其超微结构的影响，并与氨基胍（ＡＧ）进行比较。结果表明，ＨＥ与ＡＧ一样，均可明显降低神经组织中自发荧光的非酶糖基化终产物（ＡＧＥ＿ｓ）含量，并可改善ＭＮＣＶ，减轻神经脱髓鞘等病理改变。提示橙皮苷对ＳＴＺ－糖尿病大鼠神经病变有预防作用。
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| 关 键 词： | 糖尿病，实验性，神经传导，橙皮苷 |
Effects of hesperidin on function and structure in peripheral nerve of streptozocin-induced diabetic rats |
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| Wang Xin-Jia,He Guo-Fen,Zhang Hui,Zhangzhi-Li. Effects of hesperidin on function and structure in peripheral nerve of streptozocin-induced diabetic rats[J]. Chinese Journal of Pathophysiology, 1996, 0(6) |
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| Authors: | Wang Xin-Jia He Guo-Fen Zhang Hui Zhangzhi-Li |
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| Abstract: | This study investigated the effect of hesperidin (HE)of nonenzymaticglycosylation,the motor nerve conduction velocity(MNCV) and ultrastructure of peripheralnerve in streptozocininduced diabetic rats,compared with aminoguanidine(AG).The resultsshowed that HE is as like as AG redueed contents of autofluoreseent advaneed glycosylatedend products(AGEs)of nerve, improved MNCV partly,and ameliorated morphology innerve fiber segmental demyelination. These findings suggest that HE may have a preventiveeffect on diabetic neuropathy. |
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