| 大豆异黄酮抑制人乳腺癌细胞生长及作用机制研究 |
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| 引用本文： | 方庆伟,刘颖,宋丹凤,崔洪斌.大豆异黄酮抑制人乳腺癌细胞生长及作用机制研究[J].卫生研究,2002,31(5):367-369. |
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| 作者姓名： | 方庆伟 刘颖 宋丹凤 崔洪斌 |
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| 作者单位： | 哈尔滨医科大学公共卫生学院,哈尔滨,150001 |
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| 基金项目： | 国家自然科学基金 (No .30 10 0 151) |
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| 摘 要： | 采用体外细胞培养的方法 ,探讨大豆异黄酮对体外培养的人乳腺癌MCF - 7细胞生长的作用及作用机制。结果表明 ,大豆异黄酮抑制MCF - 7细胞生长 ,诱导MCF - 7细胞凋亡。蛋白水平检测表明大豆异黄酮可使MCF - 7细胞iNOS表达升高。结果提示大豆异黄酮抑制MCF - 7细胞生长 ,诱导细胞凋亡 ,并主要是通过调节iNOS基因表达实现的
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| 关 键 词： | 大豆异黄酮 乳腺癌细胞株 细胞凋亡 基因表达 |
| 文章编号： | 1000-8020(2002)05-0367-03 |
Effect of isoflavone on human breast cancer cell line MCF-7 and its probable mechanism |
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| Fang Qingwei,Liu Ying,Song Danfeng,Cui Hongbin.Effect of isoflavone on human breast cancer cell line MCF-7 and its probable mechanism[J].Journal of Hygiene Research,2002,31(5):367-369. |
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| Authors: | Fang Qingwei Liu Ying Song Danfeng Cui Hongbin |
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| Institution: | Department of Public Health, Harbin Medical University, Harbin 150001, China. |
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| Abstract: | The effects of isoflavone on human breast cancer cell line MCF-7 growth and apoptosis and its probable mechanisms were studied in vitro. The results showed that isoflavone could significantly inhibit the growth and induce the apoptosis of MCF-7 cells. Western Blotting showed that isoflavone increased iNOS protein expression. These results suggested that isoflavone significantly inhibited the MCF-7 growth and induced cell apoptosis by regulating iNOS gene expression. |
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| Keywords: | isoflavone breast cancer cell line cell apoptosis gene expression |
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