椎动脉型颈椎病血浆ET、NO的变化

为验证研究椎动脉型颈椎病(CSA)与血浆ET(内皮素)、NO(一氧化氮)的相关性,探讨椎动脉型颈椎病的发病机理.选典型的椎动脉型颈椎病患者46例称CSA组,其中20例合并神经根型称CSAN组,同时设立神经根型组20例称N组,正常对照组46例,分别检测各组样本血浆ET、NO水平,同时对46例椎动脉型颈椎病患者中8例发作期作血浆ET、NO检测.结果显示8例椎动脉型颈椎病发作期血浆ET、NO水平远远高于其他各组(P＜0.05);椎动脉型颈椎病组稳定期ET亦明显高于正常对照组(P＜0.05),而NO则低于正常对照组(P＜0.05);椎动脉型颈椎病合并神经根型组血浆ET高于纯神经根型组(P＜0.05),NO水平低于纯神经根组;纯神经根型组血浆ET、NO水平与正常对照组无明显差异(P＞0.05).表明椎动脉型颈椎病与血浆ET、NO明显相关性,推测血浆ET与NO可能参与了椎动脉型颈椎病的发病.

THE PLASMA ET AND NO CHANGES IN VERTEBRAL-ARTERY-TYPE CERVICAL SPONDYLOSIS

The objective of the paper is to study and verify the relation of vertebral-artery-type cervical spondylosis (CSA) to plasma ET and NO and to explore the pathogenesis of CSA. Forty-six typical CSA cases were selected as CSA group, and 20 of them were complicated with nerve-root-type symptoms and taken as CSAN group; another 20 CSA cases of pure nerve-root type were used as N group, and 46 normal volunteers were used as the normal control (C) group; the plasma ET and NO levels of all group were determined, respectively and those of 8 cases in CSA group were determined at the attack stage. The results showed: (1) the ET and NO levels of 8 cases determined at the attack stage far higher than those of other groups (P < 0.05); (2) the ET levels in CSA group at the stable stage significantly higher but the NO levels lower than those of C group (P < 0.05); and (3) the ET levels of CSAN group higher (P < 0.05) but the NO level lower than those of N group; (4) the ET and NO levels of N group had no significant difference from those of C group (P > 0.05), suggesting that CSA has a obvious relation to the plasma ET and NO levels, which could participate in CSA attack.