复方甘草酸苷联合单磷酸阿糖腺苷对YMDD变异慢性乙型肝炎患者疗效观察

目的通过复方甘草酸苷(美能)联合单磷酸阿糖腺苷(单磷酸阿糖腺苷)治疗有YMDD变异的慢性乙肝患者,观测肝功能、HBV-DNA、T淋巴细胞亚群分类变化,探讨治疗组疗效及复方甘草酸苷辅助治疗作用。方法60例患者随机分治疗组30例,予复方甘草酸苷联合单磷酸阿糖腺苷静滴4周,后继用复方甘草酸苷片至16周;对照组30例,甘利欣联合单磷酸阿糖腺苷静滴疗程同治疗组,治疗前、后4周、8周、16周观测肝功能、HBV-DNA、T淋巴细胞亚群分类。结果治疗组肝功能改善明显、HBV-DNA转阴率达53.33%、CD4水平及CD4/CD8比例提高与对照组比均明显,有显著性差异(P<0.05)。结论复方甘草酸苷联合单磷酸阿糖腺苷治疗能明显改善肝功能,增强抗病毒作用,还能改善患者免疫功能,有利于炎症恢复。

Compound Glycyrrhizin associated with ARA-AMP in treating chronic hepatitis B patients with YMDD Mutation

OBJECTIVE To observe the change of liver function,HBV-DNA,T-lymphocyte subgroup cbssification by.associating compound Glycynhizin with.ARA-AMP in the treatment of chronic hepatitis B patients with YMDD mutation;to investigate the assist-treating function of compaund Glycyrrhizin.METHODS 60patients were randomly half-to-half put into treatment group and comparision group.The treatment group received injection of compound Glycyrrhizin associated with ARA-AMP for4 weeks,followed up for another12weeks with taking compound Glycyrrhizin tablets.The comparision group received injection of Diammonium Glycyrrhinate associated with ARA-AMP(the same course ditto).Patients'liver tunction,HBV-DNA,and T-lymphocyte subgroup classification in both groups were checked before and after 4 weeks,8weeks,16weeks of the treatment. RESULTS Treatment group's liver function improved obviously.53.33% of the patients became negative in HBV-DNA.CD4 level and the proportion of CD4 to CD8 in creased comparatively.The 2 groups differed significantly(P<0.05).CONCLUSION The association of copound Glycyrrhizin with ARA-AMP can obviously improve live function,strengthen anti-virus function,and promote patients'immunity function as well as advance the inflammation restoration.