分次与单次口服PEG-EP进行肠道准备的效果观察

目的探讨分次与单次口服聚乙二醇电解质散(PEG-EP)进行结肠镜检查前肠道准备的清洁效果和耐受性。方法将432例进行结肠镜检查的无症状个体,随机分为A组(分次口服)和B组(单次口服)。A组于检查前夜8时和检查当日5时分别口服半包PEG-EP,B组于检查当日5时一次性口服1包PEG-EP(65.56g/袋),比较两组肠道准备的清洁效果和不良反应的发生情况。结果 A组肠道准备的清洁效果优于B组(P0.05),A组患者的耐受性优于B组(P0.05)。结论与单次口服相比,分次口服PEG-EP,既可以保证更好的肠道清洁效果,又减少不良反应,患者耐受性好,容易接受,值得临床推广应用。

Observation on effect of fractionated dose and single dose oral compound polyethylene glycol electrolyte powder for bowel preparation

Objective To evaluate the cleanliness and tolerance of fractionated dose versus single dose polyethylene glycol electrolyte powder (PEG-EP) bowel preparation regimens for colonoscopy. Methods A total of 432 asymptomatic individuals undergoing colonoscopy were enrolled and randomly assigned into 2 groups. Group A received 1/2 bag of PEG-EP at 8:00 pm before the check the first time, and 1/2 bag at 5:00am on the same day,respectively;group B received a single dose of PEG-EP(65.56g/bag) at 5:00am on the day of the check.The degree of bowel cleanness and the incidence of untoward effect were compared between 2 groups. Results The cleanliness of colon in groupa had a better effect than group A(P<0.05),and less group A complained PEG-EP related nausea(P<0.05).Conclusion Fractionated dose PEG-EP regimen provides a better colonic cleansing quality and tolerance for bowel preparation of colonoscopy,which is superior to single dose regimen.