T-Lymphocyte subpopulations in Crohn's disease: Definition by monoclonal antibodies |
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Authors: | M. Pfreundschuh B. Bader Prof. Dr. G. E. Feurle |
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Affiliation: | (1) Medizinische Universitäts-Poliklinik, Hospitalstr. 3, D-6900 Heidelberg, Germany |
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Abstract: | Summary Thirty-two patients with Crohn's disease (CD) and 32 age- and sex-matched controls were studied for T lymphocytes and T-lymphocyte subpopulations in the peripheral blood, using monoclonal antibodies defining the helper/inducer and the suppressor/cytotoxic compartment. T cells were reduced in patients with CD (P<0.05), and this reduction was more pronounced in patients with active discase (P<0.01). This T-cell deficiency involves helper and suppressor cells proportionally. The proportion of helper and suppressor cells in CD was independent of disease activity and therapy. We conclude that the T-cell deficiency in CD is a secondary event, and that there is no derangement in the immunoregulatory ratio (helper to suppressor cells) in CD which might have served as an explanation for a possible autoimmune mechanism in the pathogenesis of this disease. |
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Keywords: | Crohn's disease T lymphocytes Monoclonal antibodies |
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