In vitro inhibition of Helicobacter pylori growth and adherence to gastric mucosal cells by Pycnogenol |
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Authors: | Rohdewald Peter Beil Winfried |
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Affiliation: | 1. Institute for Pharmaceutical Chemistry, Westf?lische Wilhelms‐Universit?t Münster, D‐48161 Münster, Germany;2. Department of Pharmacology, Medizinische Hochschule Hannover, D‐30625 Hannover, Germany |
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Abstract: | The emergence of antibiotic resistant H. pylori strains has necessitated the identification of alternative additive therapies for the treatment of this infection. The study tested whether a specific pine bark extract (Pycnogenol is effective in inhibiting the growth and adherence of H. pylori in vitro. Inhibition of H. pylori growth by Pycnogenol was tested in liquid medium as well as in an in vitro model by using sessile bacteria attached to AGS cells. Adherence was determined by co-incubation of gastric cells with Pycnogenol and H. pylori in vitro. Pycnogenol inhibited H. pylori growth in suspension with an MIC(50) of 12.5 microg/mL. Growth of H. pylori in infected cells was reduced to 10% of the control value by 125 microg/mL Pycnogenol. Adherence of H. pylori to gastric cells was reduced by 70% after 3 h incubation with 125 microg/mL Pycnogenol. The results show a significant, yet limited inhibition of growth and adherence of H. pylori to gastric cells by Pycnogenol. In vivo studies have to demonstrate the clinical relevance of these findings. |
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Keywords: | Pycnogenol® Helicobacter pylori adherence bacteriostatic effect |
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