| 玳玳黄酮自微乳化微丸的体外溶出性 |
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| 引用本文： | 黄庆德,吴晓青,陈丹,程清,黄群.玳玳黄酮自微乳化微丸的体外溶出性[J].中国医院药学杂志,2012(15):1162-1165. |
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| 作者姓名： | 黄庆德 吴晓青 陈丹 程清 黄群 |
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| 作者单位： | 福建中医药大学药学院 |
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| 基金项目： | 福建省科技计划重点项目(编号:2010Y0030);福建省科技计划项目(编号:2010Y2004);福建省自然科学基金项目(编号:2010J01189) |
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| 摘 要： | 目的:研究玳玳黄酮自微乳化微丸中柚皮苷和新橙皮苷的体外溶出度。方法:运用HPLC法测定玳玳黄酮自微乳化微丸在纯化水中柚皮苷和新橙皮苷的溶出度,分别用零级动力学方程、一级动力学方程和Higuchi方程对溶出数据进行拟合,并采用相似因子(f2)分析溶出曲线。结果:玳玳黄酮自微乳化微丸溶出过程以一级动力学方程拟合最佳。柚皮苷和新橙皮苷溶出曲线的f2为92.48。结论:玳玳黄酮自微乳化微丸中柚皮苷和新橙皮苷在体外释放动力学符合一级动力学方程,能够从自微乳化微丸中同歩释放。
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| 关 键 词： | 玳玳 自微乳化药物传递系统 微丸 柚皮苷 新橙皮苷 溶出度 |
Study on the dissolution of the self-microemulsifying pellet of Daidai Flavones |
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| HUANG Qing-de,WU Xiao-qing,CHEN Dan,CHENG Qing,HUANG Qun.Study on the dissolution of the self-microemulsifying pellet of Daidai Flavones[J].Chinese Journal of Hospital Pharmacy,2012(15):1162-1165. |
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| Authors: | HUANG Qing-de WU Xiao-qing CHEN Dan CHENG Qing HUANG Qun |
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| Institution: | (Department of Pharmacy,Fujian University of TCM,Fuzhou Fujian 350108,China) |
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| Abstract: | OBJECTIVE To study the dissolution of naringin and neohesperidin in the self-microemulsifying pellet of flavones of Daidai.METHODS With distilled water as dissolution medium,the dissolution of naringin and neohesperidin in self-microemulsifying pellet of daidai were investigated by HPLC method.The zero and first-order dynamic equation、Higuchi equation were applied to simulate the drug release data.Meanwhile the dissolution curves were evaluated by calculating the analogical factors(f2).RESULTS The drug release of self-microemulsifying pellet of flavones of Daidai was most following the first-order release kinetics.The f2 between naringin and neohesperidin was 92.48.CONCLUSION Both the naringin and neohesperidin release of self-microemulsifying pellet of flavones of Daidai conform the first-order release kinetics,and they can simultaneously release. |
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| Keywords: | Daidai self-microemulsifying drug delivery system pellet naringin neohesperidin dissolution |
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