Synthesis,characterization and biological evaluation of some novel 2-substituted mercaptobenzimidazole derivatives. |
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| Authors: | Malladi Srinivas Reddy Ravinder Nath Anisetti K. Durga Prasad Santanu Sannigrahi P. Arvinda Reddy |
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| Affiliation: | (1) University College of Technology, Osmania University, Hyderabad, 500007, Andhra Pradesh, India;(2) Natco Research Center, Sanath Nagar, Lab-4, Hyderabad, India;(3) Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, West Bengal, India;(4) Department of Pharmaceutical Chemistry, C. L. Baid Metha College of Pharmacy, Chennai, 600096, Tamilnadu, India;(5) H. No.: 2-2-312, Naimnagar, Hanamkonda, Dist-Warangal, Andhra Pradesh, 506001, India |
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| Abstract: | Synthesis and biological assessment of six novel 2-substituted mercaptobenzimidazole derivatives is performed. The title compounds are characterized by their analytical and spectral data. All the synthesized compounds are screened for their anti-ulcer and anti-microbial activity. 2-(1H-benzimidazole-2-sulfinyl) –N-(4-benzyloxy-phenyl)-acetamide, N-(4-benzyloxy-phenyl)-4-(1H-benzimidazole-2-sulfinyl)-butyramide, N-(4-benzyloxy phenyl)-4-(5-methoxy 1H-benzimidazole-2-sulfinyl)-butyramide showed significant antiulcer activity. All the compounds moderate antibacterial and antifungal activity. |
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