Transplantation of human umbilical cord blood mesenchymal stem cells to treat a rat model of traumatic brain injury |
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| Authors: | Junjian Zhao Naiyao Chen Na Shen Hui Zhao Dali Wang Jun Shi Yang Wang Xiufeng Cui Zhenyu Yan Hui Xue Affiliated Hospital of Hebei United University Tangshan Hebei Province China Tianjin |
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| Affiliation: | Key Laboratory of Food Biotechnology, Tianjin University of Commerce, Tianjin 300134, China 3College of Life Science, Hebei United University, Tangshan 063000, Hebei Province, China |
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| Abstract: | In the present study, human umbilical cord blood mesenchymal stem cells were injected into a rat model of traumatic brain injury via the tail vein. Results showed that 5-bromodeoxyuridine-labeled cells aggregated around the injury site, surviving up to 4 weeks post-transplantation. In addition, transplantation-related death did not occur, and neurological functions significantly improved. Histological detection revealed attenuated pathological injury in rat brain tissues following human umbilical cord blood mesenchymal stem cell transplantation. In addition, the number of apoptotic cells decreased. Immunohistochemistry and in situ hybridization showed increased expression of brain-derived neurotrophic factor, nerve growth factor, basic fibroblast growth factor, and vascular endothelial growth factor, along with increased microvessel density in surrounding areas of brain injury. Results demonstrated migration of transplanted human umbilical cord blood mesenchymal stem cells into the lesioned boundary zone of rats, as well as increased angiogenesis and expression of related neurotrophic factors in the lesioned boundary zone. |
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| Keywords: | angiogenesis basic fibroblast growth factor brain-derived neurotrophic factor human umbilical cord blood mesenchymal stem cells nerve growth factor traumatic brain injury vascular endothelial growth factor |
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