| 大承气汤对肠源性内毒素血症大鼠组织PLA_2、SOD活性变化的影响 |
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| 引用本文： | 沈长虹,田在善,李东华. 大承气汤对肠源性内毒素血症大鼠组织PLA_2、SOD活性变化的影响[J]. 中国中西医结合外科杂志, 1996, 0(6) |
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| 作者姓名： | 沈长虹 田在善 李东华 |
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| 作者单位： | 天津市中西医结合急腹症研究所 |
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| 摘 要： | 采用静注５－ＨＴ、Ｐｂ－Ａｃｅｔ同时口灌ＬＰＳ对大鼠进行肠源性内毒素血症造模。造模后三小时，测血、组织ＰＬＡ２和ＳＯＤ活性。结果表明，模型组大鼠血清、肺、肝、肾组织匀浆的ＦＬＡ２活性明显高于正常组，而大承气汤治疗组则与正常组无异；相反模型组肺、肝、肾组织匀浆ＳＵＤ活性，则较正常组明显下降，而大承气汤治疗组则与正常组无异，说明大承气汤在肠源性内毒素血症病理形成过程中能明显抑制ＰＬＡ２活性的升高，有益于减轻组织的损害；此外，又可阻止ＳＯＤ活力的下降，从而增强对过量产生的Ｏ２的消除能力。
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| 关 键 词： | 磷脂酶A_2（PLA_2），超氧化物歧化酶（SOD），肠源性内毒素血症（EETM） |
EffectofDTontheChangesoftheActivityofPLA2andSODintissueofEnterotoxemiaRats |
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| ShenChang-hong,TianZai-shan,LiDong-huaTianjinInstituteofAcuteAbdominalDieasesofIntegratedTraditionalChineseandWesternMedicine. EffectofDTontheChangesoftheActivityofPLA2andSODintissueofEnterotoxemiaRats[J]. Chinese Journal of Surgery of Integrated Traditional and Western Medicine, 1996, 0(6) |
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| Authors: | ShenChang-hong TianZai-shan LiDong-huaTianjinInstituteofAcuteAbdominalDieasesofIntegratedTraditionalChineseandWesternMedicine |
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| Abstract: | heanimalmodelofenterotoxemiawasinducedbygivingLPSorallyandintravenuuslyinjectedwifh5-HTandleadacetatesimultaneouslytorats.Theanimalsweredividedintothreegroups:normalgroup,modelgroupandDTtreatinggroup.3hoursafterthemodelwasmadePLA2activityinserumandPLA2andSODactivityintissuehomogenatesweredetect-ed.TheresultsshowedthatPLA2activityinserumandinlung,liverandkidneyhomo-genatesofmodelratsweremuchhigherthannormalgrouprats.TheresultofDTtreatinggroup,however,showednodifferencewithnormalgroup.Onthecontrary,SODactivityintissuehomo-genatesofmodelratsshowedsignificantdecreasecomparedwithnormalrats.Butltdidn-tshowanydifferenceinDTtreainggroupwithnormalgroup.ltsuggestedthatDTcouldinhibittherisingofPLA2activityandthedecreasingofSODactivityintheformingofenterotoxemia,whichisbeneficialforalleviatingtissueinjury.Thelatterchangescouldre-inforcetheclearingabilityofextra-generatedO2. |
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| Keywords: | phosphlipaseA2(PLA2) superuxidedismutase(SOD) enterotoxemia(EETM) |
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