产后甲状腺炎发病机制的研究进展

产后甲状腺炎是一种发生于产后一年内的自身免疫性疾病,其患病率较高,表现为暂时性或永久性的甲状腺功能障碍。目前认为,妊娠期的免疫抑制在产后消失,出现暂时性免疫反应增加是引起产后甲状腺炎的主要因素,同时一些细胞因子在产后甲状腺炎的自行缓解过程中起到积极作用。此外,神经-内分泌-免疫网络调节、遗传因素、微嵌合体及环境因素等的相互作用,影响了产后甲状腺炎的发生、发展。

Progress on Mechanisms of Postpartum Thyroiditis

Postpartum thyroiditis(PPT)is a thyroid autoimmune disorder which occurring in the first year after delivery.The prevalence of PPT is quite high and its clinical features show transient or permanent thyroiditis dysfunction.At present,it is considered that the transient immunologic flare in the postpartum period following the immune suppression during pregnancy is the factor to induce postpartum thyroiditis.Meanwhile,some cytokines lead an active effect in the recovery of postpartum thyroiditis.In addition,the interaction of neuro-endocrine-immune network regulations,genetic agents,microchimera and environment agents have also contributions to the occurrence and development of PPT.