Antioxidant Therapy with N-Acetylcysteine Plus Mesalamine Accelerates Mucosal Healing in a Rodent Model of Colitis |
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Authors: | Ali Siddiqui MD Hanumantha Ancha MD Dustin Tedesco Stanley Lightfoot MD Charles A Stewart PhD Richard F Harty MD |
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Institution: | (1) Division of Gastroenterology, Department of Medicine, Oklahoma City, Oklahoma, USA;(2) Department of Pathology, University of Oklahoma Health Sciences Center and Oklahoma City Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma, USA;(3) Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA;(4) Department of Gastroenterology, Everett Tower, 7 North Pavilion, Room 526, 1200 Everett Drive, Oklahoma City, Oklahoma 73104, USA |
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Abstract: | The aims of this study were to examine the ability of the antioxidant N-acetylcysteine (NAC) and mesalamine (5-ASA) alone and in combination to affect TNBS-induced colitis in rat. Three days following induction of TNBS colitis rats were randomized to receive daily intracolonic treatment with NAC, 5-ASA, and NAC plus 5-ASA for 5 or 8 days. At the end of the treatment period macroscopic and microscopic colonic injuries were scored. Myeloperoxidase (MPO) activity and cytokine gene expression were measured in colonic tissues. Results indicated that treatment with NAC plus 5-ASA caused a significantly greater reduction in colonic injury than either agent alone. Furthermore, combination therapy inhibited significantly MPO activity and inflammatory cytokine gene expression in the distal colon of TNBS-treated animals. The beneficial effects of NAC plus 5-ASA on reduction of colonic injury and promotion of healing were most evident after 8 days of treatment. |
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Keywords: | N-acetylcysteine plus mesalamine colitis |
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