| 多发性硬化患者血清和脑脊液中白细胞介素-6的变化及其意义 |
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| 引用本文： | 戴如娟,李绍英,王嗣欣,刘长喜. 多发性硬化患者血清和脑脊液中白细胞介素-6的变化及其意义[J]. 中国神经免疫学和神经病学杂志, 1997, 0(1) |
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| 作者姓名： | 戴如娟 李绍英 王嗣欣 刘长喜 |
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| 作者单位： | 中国医科大学第一临床学院神经科!沈阳，110001，辽宁省人民医院神经科，中国医科大学第一临床学院神经科!沈阳，110001，承德医学院附属医院神经科，辽宁本溪市中心医院神经科 |
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| 摘 要： | 本研究应用生物学方法检测27例多发性硬化（MS）患者血清和脑脊液（CSF）白细胞介素-6（IL－6）水平，以探讨IL－6在MS发病中的作用。结果显示MS患者血清IL-6水平显著高于其他非炎症性神经病（NIND）组及正常对照（NC）组，其CSFIL－6水平亦显著高于NIND组；但MS患者血清与CSFIL-6水平不呈线性相关，血清IL-6水平随病情稳定而下降。本研究结果提示IL－6可能参与MS的免疫病理过程。
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| 关 键 词： | 多发性硬化 白细胞介素-6 |
The Changes of the Contents of Interleukin-6 in Serum and Cerebrospinal Fluid and Its Significance in Patients with Multiple Sclerosis |
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| Dai Rujuan,Li Shaoying, Wang Shixin ,Liu Changxi. The Changes of the Contents of Interleukin-6 in Serum and Cerebrospinal Fluid and Its Significance in Patients with Multiple Sclerosis[J]. Chinese Journal of Neuroimmunology and Neurology, 1997, 0(1) |
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| Authors: | Dai Rujuan Li Shaoying Wang Shixin Liu Changxi |
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| Abstract: | To investigate the role of interleukin-6 (IL-6) in multiple sclerosis (MS), we measuredIL-6 levels in serum and cerebrospinal fluid (CSF) from 27 patients with MS, 20 patientswith other non-inflammatory neurological diseases (NIND) and 20 normal controls (NC) us-ing a sensitive bioassay. The results showed that serum and CSF IL-6 levels were signifi-cantly higher in MS than NIND (P<0. 01) and NC (P<0. 01 ). No relationship was ob-served between serum IL-6 and CSF. Serum IL-6 levels were high at onset and fell alongwith stablness of patient's condition. This study indicated that IL-6 participate in im-munopathological process of MS possibly by activating B lymphocyte's function. |
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| Keywords: | multiple sclerosis interleukin-6 |
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