Hyperphagia and obesity in rats with bilateral ibotenic acid-induced lesions of the ventromedial hypothalamic nucleus |
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Authors: | Nobuaki Shimizu, Yutaka Oomura, Carlos R. Plata-Salam n,Masatoshi Morimoto |
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Affiliation: | Nobuaki Shimizu, Yutaka Oomura, Carlos R. Plata-Salamán,Masatoshi Morimoto |
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Abstract: | Macro-electrophoretic applications of the cellular neurotoxin ibotenic acid into the ventromedial hypothalamic nucleus (VMH) resulted in hyperphagia and obesity in male rats. Histological examination showed a reduction in the number of neuronal VMH cell bodies with glial proliferation without evidence of non-specific damage. This supports the hypothesis that hyperphagia and obesity after VMH lesions are related to destruction of neurons intrinsic to the VMH. |
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Keywords: | Rat Ventromedial hypothalamic nucleus Ibotenic acid Food intake Hyperphagia Body weight Obesity |
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