比索洛尔对原发性高血压患者左室肥厚逆转效应

目的: 探讨比索洛尔对原发性高血压病左室肥厚的逆转作用。方法: 选择40例轻中度高血压病伴左室肥厚患者，口服比索洛尔24周，测量服药前后血压变化；通过超声心动图测量患者服药前后舒张末期室间隔厚度（LVST），舒张末期左室后壁厚度（LVPWT），左室舒张末内径（LVEDD），左心室质量指数（LVMI）。检测服药前后血清中Ⅲ型前胶原（PCⅢ），胰岛素样生长因子（IGF-I），肿瘤坏死因子-α（TNF-α）的变化。结果: 治疗后上述指标较治疗前明显减低，差异有显著性（P<0.01）。结论: 比索洛尔能有效降低血压并逆转左室肥厚，其机制可能与抑制IGF-I、TNF-α的生成有关。

Effect of bisoprolol on left ventricular hypertrophy

AIM: To observe the effect of bisoprolol on left ventricular hypertrophy. METHODS: Forty patients with essential hypertension and left ventricular hypertrophy (LVH) were treated with bisoprolol (2.5-10 mg/day) for 24 weeks. Blood pressure, left ventricle diastolic dimension (LVEDD), interventricular septum thickness (LVST), left ventricle mass index (LVMI), left ventricle posterior wall thickness (LVPWT), procollagen type III (PCIII), insulin-like growth factor-I (IGF-I), and tumor necrosis factor-α (TNF-α) were measured before and after treatment. RESULTS: After bisoprolol treatment, blood pressure and LVMI, LVPWT, LVST and LVEDD levels significantly decreased (P<0.01). In addition, PCIII, IGF-I and TNF-α levels also significantly decreased (P<0.01). CONCLUSION: Bisoprolol lowers hypertension and reverses LVH. The protective mechanism may be related to its ability to reduce IGF-I and TNF-α.